You can include multiple Data Adapters in a single Adapter Set, so that they can be accessed by the same client session.
This is demonstrated by the predeployed demos in Lightstreamer package (see adapters\Demo\adapters.xml).
Any of the Adapters can be Remote Adapters. In that case, the related Proxy Adapters can be configured in adapters.xml. You should only ensure that the various ports used do not conflict. Then, you need to run all the Remote .NET Adapters separately.
Please, clarify your question details, if needed.